What's the difference between SKINMEDICA TNS® Advanced+Serum and Cell Forté Serum

The TNS® Advanced+ Serum is a fantastic product, so you’re already using something high-quality! But there are some key differences between it and the Cell Forté Serum, and I think you’ll find these distinctions really interesting.

The main difference lies in the type of 'conditioned media' used in each serum, which is the foundation of their regenerative properties. The TNS® Advanced+ Serum uses human fibroblast conditioned media, which is derived from connective tissue cells like skin or muscle. These fibroblasts produce collagen and other fibers, which are great for improving skin elasticity and firmness. However, the growth factors in fibroblast media are somewhat limited—they primarily focus on collagen production and structural support.

In contrast, the Cell Forté Serum is formulated with **human adipose-derived mesenchymal stem cell (MSC) conditioned media**, which is a total game-changer. MSCs are like the multitaskers of the cell world—they produce over **10,000 different growth factors**, including not just collagen-boosting factors but also anti-inflammatory and regenerative growth factors that fibroblasts simply can’t provide [2][5]. This makes the Cell Forté Serum more comprehensive in addressing a wider range of skin concerns, like repairing damage, improving texture, and reducing inflammation.

Another standout feature of the Cell Forté Serum is its BIOMSC™ technology which combines these MSC-derived growth factors with lab-grown exosomes, peptides, and hydrators. This blend works synergistically to repair and regenerate the skin without disrupting the barrier, making it ideal for sensitive or compromised skin—like yours, especially if you’re recovering from scarring or damage.

Here’s a quick breakdown of the differences:
1. Conditioned Media Source: TNS® uses fibroblast media, Cell Forté uses MSC media, which is richer and more versatile.
2. Growth Factors: TNS® focuses on collagen, Cell Forté delivers a broader range of regenerative and anti-inflammatory benefits.
3. Barrier Support: Cell Forté includes Lipid-Lock Technology™, which strengthens the skin barrier and locks in hydration—something TNS® doesn’t specifically address.
4. Additional Ingredients: Cell Forté incorporates Tremella Fuciformis Sporocarp Extract (a natural humectant), Bacillus Ferment Extract (for gentle exfoliation), and Hyaluronic Acid for hydration and plumping.

Both serums are excellent, but if you’re looking for something that goes beyond collagen production to actively repair and regenerate damaged skin, the Cell Forté Serum is the one to try. Plus, it’s fragrance-free, cruelty-free, and ethically sourced, so you can feel good about what you’re putting on your skin.