Flat Cell Forte Serum bottle with 3 ingredient call outs.

Cell Forte Serum bottle with 4 ingredient callouts.

Asian model holding dropper with human stem cell serum to face.

Brunette Model holds dropper with human stem cell serum to face.

Clinical results Cell Forte Serum bottle

Cell Forte Serum bottle with how to instructions.

Cell Forté Serum | Human Stem Cell Skincare | Angela Caglia

Name: Cell Forté Serum | Human Stem Cell Skincare | Angela Caglia
Brand: AngelaCaglia
SKU: 16001
Price: 325.0 USD
Availability: InStock

Human stem cell technology in a first-of-its-kind anti-aging serum.

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The Most Advanced Human Stem Cell Serum for Anti-Aging

28 Days to Your Most Radiant Skin

Cell Forté is a first-to-market human stem cell serum that supports visible renewal where signs of aging first appear—on the skin's surface. Inspired by cutting-edge stem cell research and honored by Allure, Elle, Essence, The Zoe Report, Byrdie, and Oprah Daily, this luxury anti-aging serum delivers professional-grade results without a complex regimen.

Fewer steps. Faster visible results. Skin that looks more youthful, lifted, and luminous.

"At 82, I've bought cream after cream in my 82 years, but Cell Forté proved its value again and again. I love the look of my skin."
— Janice M., Age 82, Verified Customer

⭐⭐⭐⭐⭐ 4.9/5 stars from thousands of verified customers

Why Human Stem Cell Serum?

Unlike plant stem cell products, human stem cells produce growth factors your skin actually recognizes and responds to. Cell Forté uses BIOMSC technology — human mesenchymal stem cell-conditioned media — containing billions of growth factors, cytokines, and peptides that signal your skin cells to regenerate and behave younger.

This is the same regenerative technology used in medical clinics, now available for daily home use.

What Makes Cell Forté Different

Revolutionary Human Stem Cell Technology
Formulated with a proprietary, protein-rich liquid derived from human adipose Mesenchymal Stem Cells (MSCs) using advanced tissue engineering. DNA-free, cell-free, and purified to support visible skin rejuvenation.

Targeted Bio-Signals
Each micro-batch is hand-cultured to preserve a high concentration of growth factors, peptides, and other skin-supporting proteins that help improve the look of elasticity, texture, and tone.

Biomimetic Peptides
Targets visible signs of aging using lab-crafted peptides designed to mimic the skin-renewing effects of natural biological compounds.

"I am blown away! In 30 days my face is brighter, smoother, age spots are fading and fine lines are smoothing out."
— Shaun, Verified Customer

4 Serums in 1

Targets multiple signs of aging with one human stem cell serum — no layering required. Combines ingredients known to support results similar to Vitamin C, Retinol, Hyaluronic Acid, and Peptides.*

Key Visible Benefits

Improves the appearance of firmness & elasticity
Enhances radiance for a luminous, healthy-looking glow
Refines skin's texture for a silkier feel
Provides deep hydration for a plump, supple appearance

Clinically Clean + Consciously Formulated

100/100 score on the Yuka app
Fragrance-free and ethically sourced
DNA-free, cell-free, and rigorously purified
No parabens, phthalates, or fillers

Read more about the results of our third-party perception study conducted by The Benchmarking Company. CLICK HERE

DISCLAIMER: This product is a cosmetic. Statements regarding performance are based on cosmetic ingredient research and user perception studies, not clinical trials. Results may vary. Individual outcomes depend on skin type, age, and consistent usage.

How To Use

Shake well. Apply a dropper of Cell Forte Serum on your fingertips, then immediately apply to cleansed, dry face and neck in the morning and evening. You may use other products afterward as part of your everyday routine. If using Elderberry Bakuchiol Serum or other exfoliant in your routine, cut back to two to three times per week.

FOR BEST RESULTS, Angela recommends applying in the morning and evening. Each bottle should last approximately 30 days with twice daily use.

Watch Angela's Cell Forté Routine

Benefits & Features

BENEFITS:

*Reduces the appearance of sun damage
*Improves the appearance of fine lines and wrinkles
*Reduces the look of hyperpigmentation
*Improves the look and feel of the skin

FEATURES:

*Suitable for all skin types
*4 in 1 product
*Fragrance- and dye-free
*Cruelty-free
*Clean, allergen-free formulation
*Multi-level hydration
*Luxurious silky, highly absorbable texture
*Human MSC conditioned media is produced in a cGMP laboratory
*Small-batched produced

Clinical Results

RESULTS from twice daily use of Cell Forte Serum, am and pm, after a 28-day perception study with 39 women aged 40-60.

91% agreed it helped reduce the look of hyperpigmentation
90% said skin looks more youthful
87% said skin increases luminosity
85% said skin elasticity improved
85% said it fades the look of fine lines and wrinkles

Scientific and Clinical Studies

A growing body of peer-reviewed research and clinical trials supports the safety, stability, and efficacy of mesenchymal stem cell–derived conditioned media (MSC-CM) and its exosomes in improving visible signs of aging, barrier function, and overall skin quality.

Kadoya et al., 2025 (Dermatologic Surgery)

This landmark study—funded by Allergan Aesthetics and published in Dermatologic Surgery—was the first to confirm that exosomes can remain structurally stable and biologically active within a topical cosmetic formulation.
Using advanced imaging and protein analysis (TEM, NTA, and ELISA), researchers verified that the exosomes retained their intact spherical shape (~150 nm) and hallmark surface proteins (CD9, CD63, CD81) after formulation.
Proteomic and gene-expression analyses revealed enrichment in collagen, elastin, and wound-healing pathways, supporting visible improvements in skin firmness and texture.
👉 Read abstract:
https://journals.lww.com/dermatologicsurgery/fulltext/2025/09001/isolation___characterization_of_stable_exosomes_in.4.aspx

Kim et al., 2020 (Biomedical Dermatology)

In a 4-week randomized, placebo-controlled clinical trial of 60 women with photoaged skin, creams containing 5% adipose-derived mesenchymal stem cell–conditioned media (ADMSC-CM) significantly improved hydration, barrier function (reduced TEWL), pigmentation, and wrinkle depth compared with placebo.
The group using encapsulated ADMSC-CM achieved the most dramatic improvements, with no adverse events reported.
👉 Read study:
https://biomeddermatol.biomedcentral.com/articles/10.1186/s41702-020-0056-9

Lee et al., 2021 (Journal of Cosmetic Dermatology)

In a split-face, post-laser study, patients applied a moisturizer containing ADMSC-CM + niacinamide on one side and niacinamide alone on the other.
The ADMSC-CM side showed greater reductions in wrinkles, pigmentation, and redness, along with higher collagen levels and lower inflammation markers (MMP-1, MMP-2).
This demonstrates that ADMSC-CM helps restore collagen and calm inflammation for faster skin recovery.
👉 Read study:
https://pubmed.ncbi.nlm.nih.gov/33103316/

Ahn et al., 2023 (Annals of Dermatology)

Although conducted with umbilical-cord MSC-conditioned media, this split-face study found significantly faster barrier recovery, lower redness, and improved moisture retention on the MSC-treated side after laser-induced irritation.
These results support the broader benefits of MSC-derived conditioned media for sensitive, reactive, and barrier-compromised skin.
👉 Read study:
https://anndermatol.org/DOIx.php?id=10.5021/ad.21.287

Summary:

Collectively, these studies show that stem-cell-derived conditioned media and exosomes—when expertly stabilized—can help skin appear firmer, smoother, more hydrated, and visibly renewed. They also confirm that exosomes can remain stable and functional in cosmetic formulations, enhancing cellular communication, collagen production, and overall skin vitality.

(For cosmetic use only. Supports the appearance of rejuvenated skin; not intended to diagnose, treat, or cure medical conditions.)

Description

This serum reduces the appearance of fine lines and wrinkles and improves the brightness and radiance of your skin within four weeks without disrupting the skin’s natural barrier. The result is younger-acting skin, significantly enhanced brightness and clarity, and smoother texture and tone.

1 fl. oz.

Ingredients

Human Adipose Mesenchymal Stem Cell (MSC) Conditioned Media:

Conditioned media is a powerful byproduct generated when human stem cells are cultured and nurtured in a controlled environment. During this process, stem cells release powerful growth factors, cytokines, and proteins that hold the key to skin rejuvenation.

BIOMSC™️:

Proprietary blend of our protein-rich human-derived 'conditioned media' and a combination of synthetic peptides and hydrators.

Tremella Fuciformis Sporocarp Extract:

Clinically proven to be 10x more hydrating than hyaluronic acid.

Lipid Lock Technology™️:

Proprietary bio-identical natural delivery system.

Bacillus Ferment Extract:

Probiotic maintains a healthy skin microbiome, balanced pH, and strengthens the skin barrier.

Hyaluronic Acid:

Different molecular weights for extra hydration.

FULL INGREDIENT LIST:

Water (Aqua), Propanediol, Human Adipose-Derived Stem Cell Conditioned Media, sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, sh-Polypeptide-11, Acetyl Glutamine, Alanine, Allantoin, Arginine, Bacillus Ferment, Bacillus/Folic Acid Ferment Filtrate extract, Betaine, Bisabolol, Citric Acid, Glutamic Acid, Glycerin, Glycine, Hydrolyzed Eragrostis Tef Seed Extract, Hydrolyzed Eragrostis Tef Seed Extract, Hydrolyzed Hyaluronic Acid, Lecithin, Limnanthes Alba (Meadowfoam) Seed Oil, Lysine HCl, Niacinamide, Panthenol, PCA, Proline, Pullulan, Serine, Sodium Hyaluronate, Sodium Lactate, Sodium PCA, Threonine, Tremella Fuciformis Sporocarp Extract, Xanthan Gum, Sclerotium Gum, Caprylyl Glycol, Ethylhexylglycerin, 1,2-Hexanediol, Trisodium Ethylenediamine Disuccinate, Sodium Benzoate

Cell Forté Serum | Human Stem Cell Skincare | Angela Caglia

$325.00 USD

Before/After

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Frequently Asked Questions

How is it ethically sourced and derived?

The original stem cells are healthy human mesenchymal stem cells sourced from a teaspoon of adipose body (fat) from highly-vetted twenty to twenty-five-year-old volunteer donors following U.S. FDA donor qualification procedures. The stem cells are then grown in a cGMP-certified laboratory regularly audited by the FDA for use in FDA-authorized clinical trials.

The byproduct produced when stem cells are grown is called 'conditioned media,' which is used in our Cell Forte Serum. It contains no DNA.

Is there human DNA present?

No, although stem cells derived from natural human sources are employed in the production process, they are not included in the conditioned media. Instead, only naturally secreted proteins, cytokines, and growth factors are gathered, and all cells and cellular debris are eliminated using filtration procedures. This guarantees that the serum does not contain DNA or any human stem cells.

What is BIOMSC™?

The most potent stem cell active on the market, BIOMSC™️ combines protein-rich Mesenchymal Stem Cell-Conditioned Media with complementary bio-identical peptides, along with different molecular weights of hyaluronic acid and other clinically proven hydration.

Why is it so expensive?

Unlike competitors who mass-produce stem cells in bioreactors—compromising their quality—we use hand-cultured, clinical-grade stem cells to ensure purity and potency. Each bottle contains billions of growth factors, exosomes, and peptides, delivering powerful skin-rejuvenating benefits. This meticulous process guarantees optimal effectiveness, helping to reduce visible signs of aging in just four weeks. While it costs more to produce, the unparalleled quality makes it worth the investment for truly transformative skincare.

Will my skin go through a transition phase at first?

While not expected for most users, some may experience a temporary purging phase. This can happen because the product accelerates skin cell turnover, helping to shed dead cells and impurities more quickly. In some cases, this may lead to small breakouts or uneven texture at first.

This type of reaction is commonly seen with active ingredients that increase cell renewal—such as Vitamin A (Retinol), Vitamin C, and AHA/BHA acids.

If purging does occur, it’s a normal and short-lived adjustment period. It typically resolves within two weeks as your skin clears congestion and begins functioning more optimally. Most users see visibly smoother, healthier skin after this phase.